Immunodeficiency in Protein Kinase Cβ-Deficient Mice

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Science  09 Aug 1996:
Vol. 273, Issue 5276, pp. 788-791
DOI: 10.1126/science.273.5276.788


Cross-linking of the antigen receptor on lymphocytes by antigens or antibodies to the receptor results in activation of enzymes of the protein kinase C (PKC) family. Mice homozygous for a targeted disruption of the gene encoding the PKC-βI and PKC-βII isoforms develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B cells, which is similar to X-linked immunodeficiency in mice. Thus PKC-βI and PKC-βII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction.

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