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Receptor Mutations Help Slow Disease Progression<

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Science  27 Sep 1996:
Vol. 273, Issue 5283, pp. 1797-1798
DOI: 10.1126/science.273.5283.1797


Population geneticist Stephen O'Brien of the National Cancer Institute and a large group of collaborators have amassed strong confirmatory evidence that people who have two mutant copies of the gene for a chemokine receptor known as CCR5 (also known as CKR5) are highly resistant to HIV infection. The findings, published on page1856 , also indicate that people who do get infected with HIV, but have one mutant copy of the CCR5 gene, progress to AIDS more slowly than do people without the mutation.