Hierarchical Control of Lymphocyte Survival

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Science  04 Oct 1996:
Vol. 274, Issue 5284, pp. 67-68
DOI: 10.1126/science.274.5284.67


After an immune response, the body must eliminate the excess cells generated to fight the foreign invader. Recent work indicates that this removal occurs as a result of an intricate network of regulatory processes. In their Perspective, Boise and Thompson synthesize this new evidence for the control of lymphocyte number by proteases, Bcl-2-related proteins, cytokines, and adhesion factors.

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