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Linker Histones, DNA's Protein Custodians, Gain New Respect

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Science  25 Oct 1996:
Vol. 274, Issue 5287, pp. 503-504
DOI: 10.1126/science.274.5287.503


The cell nucleus is like an overcrowded archives, with DNA and proteins wound and twisted into dense packages, called chromatin. Now a series of experimental results, including one reported in this issue (p. 614), is sketching a new picture of this archive and how a protein called the linker histone helps to manage it, by either granting or denying the cell's gene-regulating proteins access to particular sequences.

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