Suppression of TNF-α-Induced Apoptosis by NF-κB

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Science  01 Nov 1996:
Vol. 274, Issue 5288, pp. 787-789
DOI: 10.1126/science.274.5288.787


Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a negative feedback mechanism results from TNF-α signaling in which NF-κB activation suppresses the signals for cell death.

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