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Hedgehog's Patterning Call Is Patched Through, Smoothly

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Science  22 Nov 1996:
Vol. 274, Issue 5291, pp. 1304-1305
DOI: 10.1126/science.274.5291.1304


The Hedgehog protein is a key signaling molecule in embryogenesis, sending a message that allows embryonic hands to tell thumb from little finger, for example. But researchers have long sought the molecular receiver for Hedgehog's message and gotten conflicting results. New studies offer a reason why: Two proteins, Patched and Smoothened, appear to work together to receive and relay the signal.