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Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

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Science  06 Dec 1996:
Vol. 274, Issue 5293, pp. 1710-1713
DOI: 10.1126/science.274.5293.1710

Article Information

vol. 274 no. 5293 1710-1713

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History: 
  • Received for publication July 2, 1996
  • Accepted for publication October 23, 1996

Author Information

  1. Benjamin Wolozin*,,
  2. Katsunori Iwasaki,
  3. Pasquale Vito,
  4. J. Kelly Ganjei,
  5. Emanuela Lacanà,
  6. Trey Sunderland,
  7. Boyu Zhao,
  8. John W. Kusiak,
  9. Wilma Wasco,
  10. Luciano D'Adamio
  1. B. Wolozin, K. Iwasaki, T. Sunderland, Unit on Alzheimer Biology, Laboratory of Clinical Science, National Institute of Mental Health, Building 10, Room 3D41, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  2. P. Vito, J. K. Ganjei, E. Lacanà, T-Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Building 4, Room 431, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  3. B. Zhao and J. W. Kusiak, Molecular Neurobiology Unit, National Institute of Aging, Cellular Neurobiology Branch, National Institute of Neurological Disorders and Stroke, Gerontology Research Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
  4. W. Wasco, Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital-East, Harvard Medical School, 149 13th Street, Charlestown, MA 02139, USA.
  5. L. D'Adamio, T-Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Building 4, Room 111, 9000 Rockville Pike, Bethesda, MD 20892, USA. E-mail: ldadamio{at}atlas.niaid.nih.gov
  1. * Present address: Department of Pharmacology, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA. E-mail: bwolozi{at}wpo.it.luc.edu
  2. To whom correspondence should be addressed.

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