Enhancement of Class II-Restricted T cell Responses by Costimulatory NK Receptors for Class I MHC Proteins

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Science  20 Dec 1996:
Vol. 274, Issue 5295, pp. 2097-2100
DOI: 10.1126/science.274.5295.2097


An important feature of the human immune system is the ability of T cells to respond to small quantities of antigen. Class II major histocompatibility complex (MHC)-restricted T cells that expressed a costimulatory natural killer (NK) cell receptor for class I MHC proteins were cloned. In the presence of low doses of superantigen, the proliferative response of these T cell clones was three- to ninefold greater when the T cells were costimulated by way of the NK receptor. Thus, the action of costimulatory NK receptors on T cells may play a significant role in initiating and sustaining immune responses.

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