eIF4G--A Multipurpose Ribosome Adapter?

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Science  24 Jan 1997:
Vol. 275, Issue 5299, pp. 500-501
DOI: 10.1126/science.275.5299.500

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Messenger RNAs are translated into protein—a complex enterprise. Now, in work from a number of laboratories, one small adapter protein is shown to be a central player in several variations on the process. In his Perspective, Hentze describes how eIF4G serves as an adapter that binds the small ribosome subunit to the messenger RNA, working in different ways when the message has a 7mG cap at its 5' end or a polyadenylated tail at its 3' end.