Alzheimer's Disease--Genotypes, Phenotype, and Treatments

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Science  31 Jan 1997:
Vol. 275, Issue 5300, pp. 630-631
DOI: 10.1126/science.275.5300.630

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What causes Alzheimer's disease? Selkoe's Perspective reviews recent research identifying four different genetic causes of Alzheimer's disease and suggests that all four point toward the deposition of amyloid beta in the brain as the initial trigger for the disease.