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Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

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Science  31 Jan 1997:
Vol. 275, Issue 5300, pp. 665-668
DOI: 10.1126/science.275.5300.665

Article Information

vol. 275 no. 5300 665-668

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 9, 1996
  • Accepted for publication November 27, 1996
  • .

Author Information

  1. Thomas F. Franke*,
  2. David R. Kaplan,
  3. Lewis C. Cantley,
  4. Alex Toker
  1. D. R. Kaplan, ABL-Basic Research Program, NCI-FCRFDC, Frederick, MD 21702, USA; and Montreal Neurological Institute, McGill University, Montreal, PQ H3A 2B4, Canada.
  2. L. C. Cantley and A. Toker, Division of Signal Transduction, BIH, Department of Cell Biology, HMS, Boston, MA 02115, USA.
  3. T. F. Franke, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research Facility and Development Center (NCI-FCRFDC), Frederick, MD 21702, USA; Montreal Neurological Institute, McGill University, PQ H3A 2B4, Canada; and Division of Signal Transduction, Beth Israel Hospital (BIH), Department of Cell Biology, Harvard Medical School (HMS), Boston, MA 02115, USA. E-mail: tfranke{at}bidmc.harvard.edu
  1. * To whom correspondence should be addressed.
  2. Present address: Boston Biomedical Research Institute, Boston, MA 02114, USA.

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