14 February 1997
Vol 275, Issue 5302

About The Cover

Expression of Fas protein (red) detected by immunohistochemistry on disarrayed thyroid tissue (magnification ~1000) from a patient with Hashimoto's thyroiditis, an autoimmune disorder. Interactions between Fas and its ligand (FasL) control several normal and pathological processes of cell death. Fas expression induced by interleukin-1 on thyroid cells constitutively expressing FasL triggers thyroid cell death and contributes to the pathogenesis of Hashimoto's thyroiditis. See 960 and the News story on 926. [Image: Giorgio Stassi]