Research NewsBiochemistry

Src Structure Crystallizes 20 Years of Oncogene Research

See allHide authors and affiliations

Science  21 Feb 1997:
Vol. 275, Issue 5303, pp. 1066
DOI: 10.1126/science.275.5303.1066

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The first known cancer-causing gene is a Jekyll-and-Hyde gene called src, which is benign in normal cells but can turn dangerous when altered by a virus or by mutations. For 20 years, researchers have sought the controls for the Src protein's on-off switch. Two papers in last week's issue of Nature now reveal the crystal structure of the inactive forms of Src and a related protein, showing how this potentially dangerous molecule is restrained in normal cells.