Research NewsHuman Genetics

Putative Cancer Gene Shows Up in Development Instead

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Science  25 Apr 1997:
Vol. 276, Issue 5312, pp. 534-535
DOI: 10.1126/science.276.5312.534

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Seven years ago, researchers announced the identification of a gene called DCC that appeared to be linked to colon cancer. Today, its absence in tumor cells is used as an important diagnostic marker, helping to identify patients who need aggressive treatment. But new studies reported in this week's issue of Nature suggest that DCC plays a key role in neural development. If so, the gene may simply lie close to an unknown tumor suppressor gene and is usually deleted along with it.