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Research Article
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
- Peter C. Maisonpierre*,
- Chitra Suri*,
- Pamela F. Jones*,†,
- Sona Bartunkova*,
- Stanley J. Wiegand,
- Czeslaw Radziejewski,
- Debra Compton,
- Joyce McClain,
- Thomas H. Aldrich,
- Nick Papadopoulos,
- Thomas J. Daly,
- Samuel Davis*,
- Thomas N. Sato*,
- George D. Yancopoulos*,‡
- P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
See allHide authors and affiliations
Science 04 Jul 1997:
Vol. 277, Issue 5322, pp. 55-60
DOI: 10.1126/science.277.5322.55
Vol. 277, Issue 5322, pp. 55-60
DOI: 10.1126/science.277.5322.55
Peter C. Maisonpierre
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Chitra Suri
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Pamela F. Jones
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Sona Bartunkova
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Stanley J. Wiegand
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Czeslaw Radziejewski
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Debra Compton
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Joyce McClain
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Thomas H. Aldrich
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Nick Papadopoulos
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Thomas J. Daly
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Samuel Davis
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Thomas N. Sato
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
George D. Yancopoulos
P. C. Maisonpierre, C. Suri, P. F. Jones, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, and G. D. Yancopoulos are at Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. S. Bartunkova and T. N. Sato are at Beth Israel–Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
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