Dictyostelium Development in the Absence of cAMP

See allHide authors and affiliations

Science  11 Jul 1997:
Vol. 277, Issue 5323, pp. 251-254
DOI: 10.1126/science.277.5323.251

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Adenosine 3′,5′-monophosphate (cAMP) and cAMP-dependent protein kinase (PKA) are regulators of development in many organisms.Dictyostelium uses cAMP as an extracellular chemoattractant and as an intracellular signal for differentiation. Cells that are mutant in adenylyl cyclase do not develop. Moderate expression of the catalytic subunit of PKA in adenylyl cyclase–null cells led to near-normal development without detectable accumulation of cAMP. These results suggest that all intracellular cAMP signaling is effected through PKA and that signals other than extracellular cAMP coordinate morphogenesis in Dictyostelium.

  • * To whom correspondence should be addressed. E-mail: akuspa{at}

View Full Text

Stay Connected to Science