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Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase

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Science  18 Jul 1997:
Vol. 277, Issue 5324, pp. 367-369
DOI: 10.1126/science.277.5324.367

Article Information

vol. 277 no. 5324 367-369

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 14, 1997
  • Accepted for publication May 29, 1997
  • .

Author Information

  1. John R. Jacobsen,
  2. C. Richard Hutchinson,
  3. David E. Cane,
  4. Chaitan Khosla*
  1. J. R. Jacobsen, Department of Chemical Engineering, Stanford University, Stanford, CA 94305–5025, USA.
  2. C. R. Hutchinson, School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
  3. D. E. Cane, Department of Chemistry, Box H, Brown University, Providence, RI 02912, USA.
  4. C. Khosla, Departments of Chemical Engineering, Chemistry, and Biochemistry, Stanford University, Stanford, CA 94305–5025, USA.
  1. *To whom correspondence should be addressed.

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