Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

See allHide authors and affiliations

Science  26 Sep 1997:
Vol. 277, Issue 5334, pp. 2002-2004
DOI: 10.1126/science.277.5334.2002

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase–deficient (MME−/−) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME / mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME / mice that received monthly intratracheal instillations of monocyte chemoattractant protein–1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.

  • * To whom correspondence should be addressed. E-mail: sshapiro{at}

View Full Text

Stay Connected to Science