Contents

Contents

• This Week in Science

  • Research in Science journals.

    Science03 Oct 1997 : 9 Full AccessRestricted Access

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• Editorial

  • The Science of Substance Abuse

    By Floyd E. Bloom

    Science03 Oct 1997 : 15 Full AccessRestricted Access

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• departments

  • Science's Next Wave: Work in Clinical Research--Without a Medical Degree

    Science03 Oct 1997 : 153 Full AccessRestricted Access

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• News

  • Weakened SIV Vaccine Still Kills

    By Jon Cohen

    Science03 Oct 1997 : 24-25 Full AccessRestricted Access

    • Summary
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  • Berkeley Facility Ranks Low on Advisory Panel's List

    By Andrew Lawler

    Science03 Oct 1997 : 25-26 Full AccessRestricted Access

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  • Furor Over Company Deal Roils AMA

    By Jocelyn Kasier

    Science03 Oct 1997 : 26 Full AccessRestricted Access

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  • Stanford Researcher Fights Dismissal in Hospital Spat

    By Constance Holden

    Science03 Oct 1997 : 27 Full AccessRestricted Access

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  • Government Bows Out of Academy Case

    By Andrew Lawler

    Science03 Oct 1997 : 28 Full AccessRestricted Access

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  • Scandal Claims Science Minister

    By Elizabeth Finkel

    Science03 Oct 1997 : 28 Full AccessRestricted Access

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  • JET Takes a Step Closer to Break-Even

    By Alexander Hellemans

    Science03 Oct 1997 : 29 Full AccessRestricted Access

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  • Staff Makes Bid to Privatize Observatory

    By Nigel Williams

    Science03 Oct 1997 : 29-30 Full AccessRestricted Access

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  • Friendly Finish Looms on Spending

    By Andrew Lawler

    Science03 Oct 1997 : 30 Full AccessRestricted Access

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  • Socialists Reverse Budget Decline

    By Michael Balter

    Science03 Oct 1997 : 31 Full AccessRestricted Access

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  • New Studies Affirm BSE-Human Link

    By Nigel Williams

    Science03 Oct 1997 : 31 Full AccessRestricted Access

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  • Near the Lights of Vegas, Chemists Are on a Roll

    By Robert F. Service

    Science03 Oct 1997 : 32-33 Full AccessRestricted Access

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  • Olefin Catalyst Keeps Things Short

    By Robert F. Service

    Science03 Oct 1997 : 33-34 Full AccessRestricted Access

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  • Males Mutate More, Bird Study Shows

    By Steven Dickman

    Science03 Oct 1997 : 34 Full AccessRestricted Access

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• ScienceScope

  • ScienceScope

    Science03 Oct 1997 : 23 Full AccessRestricted Access

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• Random Samples

  • Random Samples

    Science03 Oct 1997 : 41 Full AccessRestricted Access

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• Books et al.

  • BOOK REVIEWS

    • An Ongoing Debate

      By Wayne Hall

      Science03 Oct 1997 : 75 Full AccessRestricted Access

      • Summary
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• Perspectives

  • Chondrites and the Solar Nebula

    By Adrian Brearley

    Science03 Oct 1997 : 76-77 Full AccessRestricted Access

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  • Carbon Nanotubes for Next-Generation Electronics Devices

    By Susumu Saito

    Science03 Oct 1997 : 77-78 Full AccessRestricted Access

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  • MutT Prevents Leakiness

    By Bryn A. Bridges

    Science03 Oct 1997 : 78-79 Full AccessRestricted Access

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  • Nota Bene: Unconscious Odors

    By Pamela J. Hines

    Science03 Oct 1997 : 79 Full AccessRestricted Access

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  • Proteins from Scratch

    By William F. DeGrado

    Science03 Oct 1997 : 80-81 Full AccessRestricted Access

    • Summary
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  • Webwatch

    Science03 Oct 1997 : 81 Full AccessRestricted Access

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• Tech.Sight

  • Tech.Sight: Products

    Science03 Oct 1997 : 150-151 Full AccessRestricted Access

• Summary

  • "Science driven"

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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• Letter

  • Top Talent at NSF

    By Mary Hanson

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • Ring Laser Design

    By H. R. Bilger

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • Analogies with Meaning

    By Robert Goldberg

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • NASA Funding for Earth Science

    By Robert Harriss

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • Polio Vaccine Production

    By Stanley A. Plotkin

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • Clean Air Skepticism

    By Frederick W. Lipfert

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • Genetic Evolution of Morphology

    By Stuart A. Newman

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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  • Resonance Raman Results: Retraction

    By Thomas G. Spiro

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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• Correction

  • Corrections and Clarifications

    Science03 Oct 1997 : 17-20 Full AccessRestricted Access

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• Special News Report

  • Getting the Brain's Attention

    By Ingrid Wickelgren

    Science03 Oct 1997 : 35-37 Full AccessRestricted Access

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  • Cocaine Wreaks Subtle Damage on Developing Brains

    By Gretchen Vogel

    Science03 Oct 1997 : 38-39 Full AccessRestricted Access

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• Special Articles

  • Addiction Is a Brain Disease, and It Matters

    By Alan I. Leshner

    Science03 Oct 1997 : 45-47 Full AccessRestricted Access

    • Abstract
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  • Interpreting Dutch Cannabis Policy: Reasoning by Analogy in the Legalization Debate

    By Robert MacCoun, Peter Reuter

    Science03 Oct 1997 : 47-52 Full AccessRestricted Access

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  • Drug Abuse: Hedonic Homeostatic Dysregulation

    By George F. Koob, Michel Le Moal

    Science03 Oct 1997 : 52-58 Full AccessRestricted Access

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  • Molecular and Cellular Basis of Addiction

    By Eric J. Nestler, George K. Aghajanian

    Science03 Oct 1997 : 58-63 Full AccessRestricted Access

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  • Psychoactive Drug Use in Evolutionary Perspective

    By Randolph M. Nesse, Kent C. Berridge

    Science03 Oct 1997 : 63-66 Full AccessRestricted Access

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  • A Range of Research-Based Pharmacotherapies for Addiction

    By Charles P. O'Brien

    Science03 Oct 1997 : 66-70 Full AccessRestricted Access

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• Research Article

  • De Novo Protein Design: Fully Automated Sequence Selection

    By Bassil I. Dahiyat, Stephen L. Mayo

    Science03 Oct 1997 : 82-87 Full AccessRestricted Access

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• Reports

  • Accretion Rates of Meteorites and Cosmic Dust in the Early Ordovician

    By Birger Schmitz, Bernhard Peucker-Ehrenbrink, Maurits Lindström, Mario Tassinari

    Science03 Oct 1997 : 88-90 Full AccessRestricted Access

    • Abstract
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  • Measurements of ¹²C/¹³C, ¹⁴N/¹⁵N, and ³²S/³⁴S Ratios in Comet Hale-Bopp (C/1995 O1)

    By David C. Jewitt, Henry E. Matthews, Tobias Owen, Roland Meier

    Science03 Oct 1997 : 90-93 Full AccessRestricted Access

    • Abstract
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  • Midwinter Start to Antarctic Ozone Depletion: Evidence from Observations and Models

    By H. K. Roscoe, A. E. Jones, A. M. Lee

    Science03 Oct 1997 : 93-96 Full AccessRestricted Access

    • Abstract
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  • Time-Domain Holographic Digital Memory

    By Xiao A. Shen, An-Dien Nguyen, John W. Perry, David L. Huestis, Ravinder Kachru

    Science03 Oct 1997 : 96-100 Full AccessRestricted Access

    • Abstract
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  • Nanotube Nanodevice

    By Philip G. Collins, A. Zettl, Hiroshi Bando, Andreas Thess, R. E. Smalley

    Science03 Oct 1997 : 100-102 Full AccessRestricted Access

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  • Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling

    By Carla Inouye, Namrita Dhillon, Jeremy Thorner

    Science03 Oct 1997 : 103-106 Full AccessRestricted Access

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  • Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing

    By Lisa K. Denzin, Derek B. Sant'Angelo, Craig Hammond, Michael J. Surman, Peter Cresswell

    Science03 Oct 1997 : 106-109 Full AccessRestricted Access

    • Abstract
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  • Interdomain Interactions Underlying Activation of Cyclic Nucleotide-Gated Channels

    By Michael D. Varnum, William N. Zagotta

    Science03 Oct 1997 : 110-113 Full AccessRestricted Access

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  • Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current

    By Shan Ping Yu, Chen-Hsiung Yeh, Stefano L. Sensi, Byoung J. Gwag, Lorella M. T. Canzoniero, Z. Shadi Farhangrazi, Howard S. Ying, Min Tian, Laura L. Dugan, Dennis W. Choi

    Science03 Oct 1997 : 114-117 Full AccessRestricted Access

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  • Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

    By Yasuaki Tamura, Ping Peng, Kang Liu, Maria Daou, Pramod K. Srivastava

    Science03 Oct 1997 : 117-120 Full AccessRestricted Access

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  • Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

    By Hiroyuki Shibata, Kaoru Toyama, Hisashi Shioya, Masaki Ito, Morihisa Hirota, Sumitaka Hasegawa, Hiroshi Matsumoto, Hiroshi Takano, Tetsu Akiyama, Kumao Toyoshima, Ryunosuke Kanamaru, Yumi Kanegae, Izumu Saito, Yusuke Nakamura, Kiyotaka Shiba, Tetsuo Noda

    Science03 Oct 1997 : 120-123 Full AccessRestricted Access

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  • Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

    By Vassiliki A. Boussiotis, Gordon J. Freeman, Alla Berezovskaya, Dwayne L. Barber, Lee M. Nadler

    Science03 Oct 1997 : 124-128 Full AccessRestricted Access

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  • Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage

    By F. Taddei, H. Hayakawa, M.-F. Bouton, A.-M. Cirinesi, I. Matic, M. Sekiguchi, M. Radman

    Science03 Oct 1997 : 128-130 Full AccessRestricted Access

    • Abstract
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  • Functional Dynamics of GABAergic Inhibition in the Thalamus

    By Uhnoh Kim, Maria V. Sanchez-Vives, David A. McCormick

    Science03 Oct 1997 : 130-134 Full AccessRestricted Access

    • Abstract
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  • Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

    By Michael M. Ollmann, Brent D. Wilson, Ying-Kui Yang, Julie A. Kerns, Yanru Chen, Ira Gantz, Gregory S. Barsh

    Science03 Oct 1997 : 135-138 Full AccessRestricted Access

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  • NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily

    By Götz-Ulrich von Bülow, Richard J. Bram

    Science03 Oct 1997 : 138-141 Full AccessRestricted Access

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  • Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

    By Batool Ossareh-Nazari, Françoise Bachelerie, Catherine Dargemont

    Science03 Oct 1997 : 141-144 Full AccessRestricted Access

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• Technical Comments

  • The Possibility of Ice on the Moon

    By S. J. Weidenschilling

    Science03 Oct 1997 : 144-145 Full AccessRestricted Access

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