Reuse of B Lymphocyte in Germinal Centers

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Science  10 Oct 1997:
Vol. 278, Issue 5336, pp. 238-239
DOI: 10.1126/science.278.5336.238

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Recombination of subsegments during immune development allows the genes for antibodies to be made as an enormously diverse family. Now two reports on pages 298 and 301 of this issue describe the reawakening of recombination later in the life of B lymphocytes in the germinal centers where they undergo secondary recombination. In his Perspective, Liu discusses these findings and the possible function of this process.