Research NewsGenetics

Fast-Forward Aging in a Mutant Mouse?

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Science  07 Nov 1997:
Vol. 278, Issue 5340, pp. 1013
DOI: 10.1126/science.278.5340.1013

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The infirmities and breakdowns that herald old age are so predictable that some scientists believe our genes evolved with a "warranty" that runs out after a set period. In this week's issue of Nature, a team in Japan reports what may be a clue to this warranty: mice defective in just a single gene that resemble senior citizens by the time they're only 60 days old. Because the defective gene in the mice is also found in humans, it is believed that unraveling its functioning could lead to a better understanding of the human aging process.