09 January 1998
Vol 279, Issue 5348

About The Cover

Alzheimer's is characterized by short-term memory loss and plaques and tangles in the cerebral cortex. Aberrant ubiquitin protein, likely resulting from an RNA mutation, is detectable in plaques (vague spots) and tangles (flame shapes, ~40 µm long) in the hippocampus (a region involved in short-term memory) from an Alzheimer's patient. This mutation mechanism is likely a factor in nonfamilial Alzheimer's and other neurodegenerative pathologies. See 242 and the News story on 174. [Image: F. W. van Leeuwen and G. van der Meulen]