Report

Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging

See allHide authors and affiliations

Science  16 Jan 1998:
Vol. 279, Issue 5349, pp. 373-377
DOI: 10.1126/science.279.5349.373

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity–directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates ofH. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains ofH. pylori.

  • * These authors contributed equally to this work.

  • Present address: Max-von Pettenkofer Institut für Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9A, D-81677 Munich, Germany.

  • Present address: Swedish Institute for Infectious Disease Control, S-105 21, Stockholm, Sweden.

  • § To whom correspondence should be addressed. E-mail: thomas.boren{at}micro.umu.se

View Full Text