Role of Vesicle-Associated Syntaxin 5 in the Assembly of Pre-Golgi Intermediates

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Science  30 Jan 1998:
Vol. 279, Issue 5351, pp. 696-700
DOI: 10.1126/science.279.5351.696

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Syntaxins are thought to function during vesicular transport as receptors on the target membrane and to contribute to the specificity of membrane docking and fusion by interacting with vesicle-associated receptors. Here, syntaxin 5 (Syn5) was shown to be an integral component of endoplasmic reticulum–derived transport vesicles. This pool, but not the target, Golgi-associated Syn5 pool, was essential for the assembly of vesicular-tubular pre-Golgi intermediates and the delivery of cargo to the Golgi. The requirement for vesicle-associated Syn5 in transport suggests a reevaluation of the basis for operation of the early secretory pathway.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: webalch{at}

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