Research Article

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

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Science  06 Mar 1998:
Vol. 279, Issue 5356, pp. 1504-1513
DOI: 10.1126/science.279.5356.1504

Article Information

vol. 279 no. 5356 1504-1513

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History: 
  • Received for publication December 1, 1997
  • Accepted for publication January 28, 1998

Author Information

  1. Matthew R. Redinbo*,
  2. Lance Stewart*,,
  3. Peter Kuhn,
  4. James J. Champoux,
  5. Wim G. J. Hol
  1. M. R. Redinbo and L. Stewart are at the Biomolecular Structure Center and Department of Biological Structure, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA. P. Kuhn is at Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94309, USA. J. J. Champoux is in the Department of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98915, USA. W. G. J. Hol is in the Departments of Biological Structure and Biochemistry, Howard Hughes Medical Institute and Biomolecular Structure Center, Box 357742, School of Medicine, University of Washington, Seattle, WA 98195, USA.

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