Conservation of T Cell Receptor Conformation in Epidermal γδ Cells with Disrupted Primary Vγ Gene Usage

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Science  13 Mar 1998:
Vol. 279, Issue 5357, pp. 1729-1733
DOI: 10.1126/science.279.5357.1729

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A feature that distinguishes γδ T cell subsets from most αβ T cells and B cells is the association of expression of single T cell receptor (TCR) γ and δ variable (V) region gene segments with specific anatomic sites. Mice lacking the TCR Vγ5 chain normally expressed by most dendritic epidermal T cells were shown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vγ5+cells. Conservation by shuffled γδ TCR chains of an idiotype associated with a specific anatomic site indicates that for TCRγδ, as for immunoglobulin, conformation is associated to a greater extent with the function or development of lymphocyte repertoires than is the use of particular gene segments.

  • * These authors contributed equally to this report.

  • To whom correspondence should be addressed. E-mail: adrian.hayday{at}

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