Special Articles

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

See allHide authors and affiliations

Science  10 Apr 1998:
Vol. 280, Issue 5361, pp. 243-248
DOI: 10.1126/science.280.5361.243

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.

  • * Present address: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Full Text

Stay Connected to Science