Thermographic Selection of Effective Catalysts from an Encoded Polymer-Bound Library

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Science  10 Apr 1998:
Vol. 280, Issue 5361, pp. 267-270
DOI: 10.1126/science.280.5361.267

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A general method is introduced for the rapid and simultaneous evaluation of each member of large encoded catalyst libraries for the ability to catalyze a reaction in solution. The procedure was used to select active catalysts from a library of potential polymer-bound multifunctional catalysts. From ∼7000 beads screened (3150 distinct catalysts), 23 beads were selected for catalysis of an acylation reaction. Kinetic experiments indicate that the most strongly selected beads are also the most efficient catalysts.

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