Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

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Science  24 Apr 1998:
Vol. 280, Issue 5363, pp. 596-599
DOI: 10.1126/science.280.5363.596

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Control of stability of β-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both β-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced β-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized β-catenin. Fragments of APC that contained a conductin-binding domain also blocked β-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs β-catenin to degradation and is located downstream of APC. InXenopus embryos, conductin interfered with wnt-induced axis formation.

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