COI1: An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility

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Science  15 May 1998:
Vol. 280, Issue 5366, pp. 1091-1094
DOI: 10.1126/science.280.5366.1091

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The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility. The wild-type allele, COI1, was mapped to a 90-kilobase genomic fragment and located by complementation of coi1-1 mutants. The predicted amino acid sequence of the COI1 protein contains 16 leucine-rich repeats and an F-box motif. It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination.

  • * Present address: Sainsbury Laboratory, John Innes Centre, Norwich, UK.

  • Present address: Biological Sciences, Wye College, Wye, Ashford, Kent, UK.

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