Research CommentariesSignal Transduction

Kinases and Phosphatases--A Marriage Is Consummated

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Science  22 May 1998:
Vol. 280, Issue 5367, pp. 1212-1213
DOI: 10.1126/science.280.5367.1212

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Covalent addition of a phosphate to enzymes and other cellular proteins often turns its activity on or off, or otherwise regulates its function. Now in his research commentary, Hafen summarizes two reports in this week's issue (Westphal and Camps) that show the intimate association and mutual regulation of the two key enzymes for controlling phosphate addition in cells--kinases and phosphatases. Hafen postulates that this interdependence will prove to be a universal property of pairs of kinases and phosphatases.