The Tetrameric Structure of a Glutamate Receptor Channel

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Science  05 Jun 1998:
Vol. 280, Issue 5369, pp. 1596-1599
DOI: 10.1126/science.280.5369.1596

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The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

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