New Gene Tied to Common Form of Alzheimer's

See allHide authors and affiliations

Science  24 Jul 1998:
Vol. 281, Issue 5376, pp. 507-509
DOI: 10.1126/science.281.5376.507

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


A common mutation in the gene encoding a protein called a-macroglobulin appears to increase the risk of the most common form of Alzheimer's disease, which occurs late in life. The number of Alzheimer's cases linked to the mutation could potentially be large, given that an estimated 30% of the population carries the mutation. The new gene and its protein, which may help scour toxins from between neurons, could also make sense of how several other proteins already implicated in Alzheimer's might contribute to the disease.