Translating Affinity into Response

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Science  24 Jul 1998:
Vol. 281, Issue 5376, pp. 528-529
DOI: 10.1126/science.281.5376.528

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At first glance, signaling molecules that interact with cell-surface receptors would seem to have only two choices--to bind to the receptor to turn it on or dissociate to turn it off. But then how can one explain the diverse responses elicited by molecules that interact with the same receptor? In his Perspective, Malissen discusses new findings, including two reports in this week's issue by Torigoe and Neumeister Kersch, that suggest a molecular solution to this mystery.