Segregation of Transcription and Replication Sites Into Higher Order Domains

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Science  04 Sep 1998:
Vol. 281, Issue 5382, pp. 1502-1505
DOI: 10.1126/science.281.5382.1502

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Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

  • * Present address: Life Imaging Systems, 195 Dufferin Avenue, Suite 300, London, Ontario N6A1K7, Canada.

  • To whom correspondence should be addressed. E-mail: berezney{at}

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