Promotion of Dendritic Growth by CPG15, an Activity-Induced Signaling Molecule

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Science  18 Sep 1998:
Vol. 281, Issue 5384, pp. 1863-1866
DOI: 10.1126/science.281.5384.1863

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Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. InXenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.

  • * To whom correspondence should be addressed. E-mail: nedivi{at}

  • Present address: Department of Brain and Cognitive Sciences and Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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