Transformation of Tooth Type Induced by Inhibition of BMP Signaling

See allHide authors and affiliations

Science  06 Nov 1998:
Vol. 282, Issue 5391, pp. 1136-1138
DOI: 10.1126/science.282.5391.1136

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10. The inhibition of BMP signaling early in mandible development by the action of exogenous Noggin protein resulted in ectopic Barx-1 expression in the distal, presumptive incisor mesenchyme and a transformation of tooth identity from incisor to molar.

  • * To whom correspondence should be addressed. E-mail: psharpe{at}

View Full Text

Stay Connected to Science