PerspectiveCell Biology

A Cellular Striptease Act

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Science  13 Nov 1998:
Vol. 282, Issue 5392, pp. 1279-1280
DOI: 10.1126/science.282.5392.1279

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Proteins on the cell surface can be cleaved by proteolytic enzymes. In the Perspective, Werb and Yan outline the many purposes of these cleavage events-to provide ligand for binding to receptors (as shown in the report by Peschon et al. on p. 1281), to eliminate ligand on receptors and to increase or decrease cell-cell interactions. Such proteolysis can be regulated and is turning out to be widely used by the cell.