PerspectiveMolecular Biology

Just the Facts of Chromatin Transcription

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Science  04 Dec 1998:
Vol. 282, Issue 5395, pp. 1836-1837
DOI: 10.1126/science.282.5395.1836

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DNA is not stuffed randomly into the nucleus of cells. Rather, it is neatly coiled around a series of histone octamers. John and Workman discuss how the cell transcribes RNA messages from such a seemingly inaccessible template. They describe a report in this issue by LeRoy et al . that identifies several proteins that help to move the nucleosomes out of the way of the transcription machinery.