Special Reviews

Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology

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Science  11 Dec 1998:
Vol. 282, Issue 5396, pp. 2012-2018
DOI: 10.1126/science.282.5396.2012

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The 97-megabase genomic sequence of the nematode Caenorhabditis elegans reveals over 19,000 genes. More than 40 percent of the predicted protein products find significant matches in other organisms. There is a variety of repeated sequences, both local and dispersed. The distinctive distribution of some repeats and highly conserved genes provides evidence for a regional organization of the chromosomes.

  • * See genome.wustl.edu/gsc/C_elegans/ andwww.sanger.ac.uk/Projects/C_elegans/ for a list of authors. Address correspondence to The Washington University Genome Sequencing Center, Box 8501, 4444 Forest Park Parkway, St. Louis, MO 63108, USA. E-mail: worm{at}watson.wustl.edu; or The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. E-mail: worm{at}sanger.ac.uk

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