Promotion of Trophoblast Stem Cell Proliferation by FGF4

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Science  11 Dec 1998:
Vol. 282, Issue 5396, pp. 2072-2075
DOI: 10.1126/science.282.5396.2072

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The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.

  • * Present address: Laboratory of Cellular Biochemistry, Veterinary Medical Science/Animal Resource Science, University of Tokyo, Tokyo, Japan 113-8657.

  • To whom correspondence should be addressed. E-mail: rossant{at}

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