T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

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Science  29 Jan 1999:
Vol. 283, Issue 5402, pp. 680-682
DOI: 10.1126/science.283.5402.680

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Although dispensable, costimulation through CD28 facilitates activation of naı̈ve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

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