MaRX: An Approach to Genetics in Mammalian Cells

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Science  19 Feb 1999:
Vol. 283, Issue 5405, pp. 1129-1130
DOI: 10.1126/science.283.5405.1129

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In this Tech.View, David Beach and his colleagues describe a new, widely applicable genetic method for analysis of gene function in mammalian cells. This MaRX system allows the inhibition of specified genes (effectively producing a null phenotype) and the subsequent analysis of the phenotype.