Behind the Headlines of Endostatin's Ups and Downs

See allHide authors and affiliations

Science  26 Feb 1999:
Vol. 283, Issue 5406, pp. 1250-1251
DOI: 10.1126/science.283.5406.1250

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Researchers have been trying for a year to replicate remarkable experiments in mice, in which a compound called endostatin hampered the growth of blood vessels that feed tumors, making cancer disappear. The experiments and the attempts to repeat them have sparked reports of a "miracle cure" one day and a "failure" the next. Behind this confusing array of stories lies a scientific saga that emphasizes how small differences in techniques, reagents, and assays can foil attempts by one lab to repeat the work of another. It shows that replication, a cornerstone of the scientific process, means different things to different people. And it also helps clarify why the media-driven frenzy about endostatin has been so confusing and frustrating to the public and scientists alike.