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Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene

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Science  05 Mar 1999:
Vol. 283, Issue 5407, pp. 1544-1548
DOI: 10.1126/science.283.5407.1544

Article Information

vol. 283 no. 5407 1544-1548

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 20, 1998
  • Accepted for publication January 29, 1999

Author Information

  1. Mounib Elchebly1,
  2. Paul Payette2,
  3. Eva Michaliszyn1,
  4. Wanda Cromlish2,
  5. Susan Collins2,
  6. Ailsa Lee Loy1,
  7. Denis Normandin2,
  8. Alan Cheng1,
  9. Jean Himms-Hagen3,
  10. Chi-Chung Chan2,
  11. Chidambaram Ramachandran2,
  12. Michael J. Gresser2,
  13. Michel L. Tremblay1,
  14. Brian P. Kennedy2,*
  1. 1 Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6.
  2. 2 Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Post Office Box 1005, Pointe Claire-Dorval, Quebec, Canada, H9R 4P8.
  3. 3 Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada, K1H 8M5.

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