Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin

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Science  12 Mar 1999:
Vol. 283, Issue 5408, pp. 1739-1742
DOI: 10.1126/science.283.5408.1739

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Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of β-catenin/Armadillo, which in turn activates gene transcription. Here theDrosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axininhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila.

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