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Complexity in Biological Signaling Systems

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Science  02 Apr 1999:
Vol. 284, Issue 5411, pp. 92-96
DOI: 10.1126/science.284.5411.92

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Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.

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