09 April 1999
Vol 284, Issue 5412

About The Cover

Cover image expansion

COVER The IkB kinase (IKK) complex is responsible for triggering inflammatory responses. However, gene ablation expriments have identified an unexpected function for the IKKa subunit of this complex-control of epidermis formation. Sections of epidermis (~30 mm tall) from normal (top) and IKKa-deficient mice (bottom) stained to visualize nuclei (purple) and nondifferentiated cells (red) reveal the marked expansion of nondifferentiated cells in mutant epidermis. See page 316. [Image: Y. L. Hu]