Special Reviews

Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host Cells

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Science  21 May 1999:
Vol. 284, Issue 5418, pp. 1322-1328
DOI: 10.1126/science.284.5418.1322

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Several Gram-negative pathogenic bacteria have evolved a complex protein secretion system termed type III to deliver bacterial effector proteins into host cells that then modulate host cellular functions. These bacterial devices are present in both plant and animal pathogenic bacteria and are evolutionarily related to the flagellar apparatus. Although type III secretion systems are substantially conserved, the effector molecules they deliver are unique for each bacterial species. Understanding the biology of these devices may allow the development of novel prevention and therapeutic approaches for several infectious diseases.

  • * To whom correspondence should be addressed. e-mail: jorge.galan{at}yale.edu

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