Technical Comments

Fas, p53, and Apoptosis

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Science  28 May 1999:
Vol. 284, Issue 5419, pp. 1431
DOI: 10.1126/science.284.5419.1431b


  • Figure 1

    Fas-induced apoptosis in the absence of p53. Apoptotic cells were detected by TUNEL staining in liver sections from p53 −/− or control mice (both on C57BL/6 background) 2 hours after intravenous injection of 100 μg of anti-Fas (Jo2) antibody. Apoptosis was detected by phosphatidylinositol (PI) staining in thymocytes fromp53 −/− or control mice 24 hours after treatment in a culture of 1.0 μg/ml antibody (Jo2) against Fas. Values are means ± SD from at least two animals.

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